Os jogos da MLB, NFL e WNBA terminaram em 21 de setembro de 2025, com várias vitórias decisivas em todas as ligas. MLB, NFL, and WNBA games concluded on September 21, 2025, with multiple decisive victories across leagues.

Em 21 de setembro de 2025, a Major League Baseball apresentou vários jogos decisivos, incluindo o 11-0 dos Padres contra os Atléticos, a vitória 7-1 dos Yankees sobre os Orioles e a vitória 6-2 dos Bravos sobre os Tigres. On September 21, 2025, Major League Baseball featured several decisive games, including the Padres' 11-0 shutout of the Athletics, the Yankees' 7-1 win over the Orioles, and the Braves' 6-2 victory over the Tigers. Os Mariners venceram os Astros 7-3, os Reds ultrapassaram os Cubs por 1-0, e os Dodgers derrotaram os Giants por 3-1. The Mariners beat the Astros 7-3, the Reds edged the Cubs 1-0, and the Dodgers defeated the Giants 3-1. Na NFL, os Chiefs derrotaram os Giants 22-9, os Vikings derrotaram os Bengals 48-10 e os Commanders venceram os Raiders 41-24. In the NFL, the Chiefs defeated the Giants 22-9, the Vikings beat the Bengals 48-10, and the Commanders overcame the Raiders 41-24. Os Eagles derrotaram por pouco os Rams 33-26, os Seahawks esmagaram os Saints 44-13 e os 49ers ultrapassaram os Cardinals 16-15. The Eagles narrowly beat the Rams 33-26, the Seahawks crushed the Saints 44-13, and the 49ers edged the Cardinals 16-15. Na WNBA, a Febre derrotou os Ases 89-73, e o Lince venceu o Mercúrio 82-69. In the WNBA, the Fever defeated the Aces 89-73, and the Lynx beat the Mercury 82-69.